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In 2009, the direct healthcare costs of respiratory diseases attributable to smoking was 27.4 billion

pmid:22311962 16

Pro-inflammatory mediator and cancer-associated chemokine CXCL8 as a prognostic indicator of tumor aggressiveness, angiogenesis, and disease progression with focus on therapeutic implications and recurrence monitoring Hema Shree K, Gayathri R, Vishnu Priya Veeraraghavan, Selvaraj J, Pratibha Ramani Oral Oncology Reports 8

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For example, travelers might only be allowed to bring a certain number of cigarettes across borders