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Reporting limits for these analyses are given in Additional file1: Table S5

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Finally, methylation levels are often correlated across multiple neighboring CpGs and this co-methylation is stronger for CpGs inside CGIs than outside CGIs ( ENZYMES OF DNA METHYLATION Methylation of DNA is catalyzed by three families of DNA methyltransferases: DNMT1, DNMT2, and DNMT3 ( DNMT1 is responsible for life-long maintenance of DNA methylation during cell division it copies DNA methylation marks from the original to the nascent strand during DNA replication (Tang et al., 2009)

In April 2022, the Relativity Assessment Workgroup identified this service with Medicare utilization of 10,000 or more that have increased by at least 100 percent from 2015 through 2020