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6.3 Mitochondria-targeted antioxidants and redox modulation Since mitochondrial reactive oxygen species (mtROS) are a key upstream trigger for mitophagy, targeting mitochondrial antioxidants has been explored as an indirect regulator of mitochondrial quality control ( In renal fibrosis models, the mitochondria-targeted antioxidant MitoTEMPO reduced pathological mtROS, restored mitophagy, and attenuated fibrotic phenotypes in renal tubular cells ( 6.4 Genetic and advanced therapeutic approaches targeting kidneylung crosstalk To achieve greater specificity, emerging therapies adopt gene modulation and targeted delivery systems

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