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13 Even the tobacco industrys own studies have concluded that in vitro toxicology tests can be successfully used both for better understanding the biological activity of cigarette smoke and for guiding the development of cigarettes with reduced toxicity. 14 Despite this fact, tobacco companies, government agencies, 15 the American Cancer Society, National Heart, Lung and Blood Institute, among other organization and, yes, even anti-smoking groups continue to test cigarettes on animals
Since it is not biologically plausible that former-EC use could have a causal effect, while current use does not, this likely indicates the influence of additional confounding factors
There are three subsets of IMs (IM1, IM2 and IM3) and all are generally immunosuppressive/tolerogenic due to their constitutive production of IL-10 [137, 138]
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