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After attachment, BEAS-2B cells were treated with WS-23 (0.45, 1.5, 4.5 mg/mL) dissolved in BEGM cell culture medium

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Another study in rats evaluated the neurotoxicant effects of prenatal and adolescent nicotine exposure and found the PNE administration produced cellular alternations including net cell losses in the midbrain, and regional enlargement of the hippocampus [164]