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The contemporary (or cigarette) profile then sees the emergence of tobacco as a mass consumption item only after the invention and mechanization of the cigarette in the late nineteenth century allows the practice of smoking to spread from the male elite down the social hierarchy and across the gender divide

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Shorter time to first cigarette after waking is one of the strongest predictors of higher nicotine dependence severity among daily smokers and has previously been associated with cotinine levels for daily smokers [34, 35]

Long-term management strategies include quitting smoking, medications for inflammation reduction and mucus thinning, pulmonary rehabilitation, and supportive care like oxygen therapy

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