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The law prohibits the introduction of new or changed e-cigarettes after the August 2016 effective date without prior FDA review

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Espinoza-Derout J, Hasan KM, Shao XM, Jordan MC, Sims C, Lee DL, Sinha S, Simmons Z, Mtume N, Liu Y, Roos KP, Sinha-Hikim AP, Friedman TC (2019) Chronic intermittent electronic cigarette exposure induces cardiac dysfunction and atherosclerosis in apolipoprotein-E knockout mice

Moreover, between October 2003 and October 2004, and October 2004 and October 2005, the average price of a packet of cigarettes has increased by only 0.16, which is the lowest yearly increase in the past two decades