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Experimental studies carried out during many years have revealed several biological mechanisms that deserve to be researched, such as angiogenesis, connective tissues, digestive system physiology, cell migration and signaling pathways

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A recent meta-analysis of 12 observational studies found that higher dietary intake of vitamin B 12 was associated with a 23% lower risk of depression compared to lower intakes, but stratifying the data revealed a significant protective association in females, not in males (99)