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The Richmond, Va.-based company said revenue, excluding excise taxes, rose about 3 percent to $4.46 billion as higher costs to promote its top-selling Marlboro brand were offset by higher prices and volumes

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[83] A direct consequence of this difference is the widespread binding of Hb by CO in the blood, the creation of COHb, and a great increase in its serum levels, resulting in a significant decrease in oxygen uptake by peripheral tissues

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