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Around 22.3% of the worlds population, primarily in low- and middle-income countries, use tobacco, with men disproportionately affected

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Abbreviations: AM (alveolar macrophage), BAL (bronchoalveolar lavage), DC (dendritic cell), e-cig (e-cigarette), e-cig vaped extract (EVE), gen (generation), h (hour), min (minute), NK (natural killer), PG (propylene glycol), THC (tetrahydrocannabinol), VG (vegetable glycerin) Introduction to E-cigarettes Tobacco has been used by humans for over 12,000 years(1)