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Nicotine is a natural chemical compound found in tobacco leaves

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After the 2006 death of Dana Reeve -- widow of actor Christopher Reeve -- many observers speculated her illness might have been triggered by her years of singing in smoke-filled nightclubs

However, the impacts of integrating different cohorts on current study findings are expected to be trivial because the data for three cohorts were collected using standardized procedures 21

Interestingly, all glycolytic intermediates (including lactate) were elevated in nicotine-exposed testes, which exhibited partial reversal post-nicotine cessation (Supplementary Fig