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Tobacco smoking (TS) is an established risk factor for ccRCC, with unknown effects on tumor pathobiology.METHODS We investigated the landscape of ccRCCs and paired normal kidney tissues using integrated transcriptomic, metabolomic, and metallomic approaches in a cohort of white males who were long-term current smokers (LTS) or were never smokers (NS).RESULTS All 3 Omics domains consistently identified a distinct metabolic subtype of ccRCCs in LTS, characterized by activation of oxidative phosphorylation (OXPHOS) coupled with reprogramming of the malate-aspartate shuttle and metabolism of aspartate, glutamate, glutamine, and histidine

Teenage boys everywhere started smoking

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The WHO recommend that the statutes and regulations governing subsidy of media productions should be amended so that any media production representing or referencing tobacco use or depicting a tobacco product, non-pharmaceutical nicotine device or tobacco brand name, trademark, marketing collateral or paraphernalia is ineligible for any form of public benefit for project development, production, marketing or distribution, including grants, loans, investments, spending rebates, tax credits or other favourable tax or trade treatment