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This is especially concerning given that low levels of nicotine exposure during adolescence can have a profound impact on neurochemistry and behavior (e.g., decreased cognitive function, enhanced drug reward), which contribute to the development of nicotine dependence, as well as substance use disorders [4, 6]

More elevated contamination classes were less frequent but present, including Moderate (4.4%), High (2.8%), Very high (0.6%), and Extremely high (2.1%)

I want to give special thanks to Debbie BrewerWest

In order to help with accounting and standardizing trade, colonial government officials would rate tobacco and compare its weight to values of pounds, shillings, and pence