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3 Results 3.1 Epidemiology Recent national surveys among Italian adolescents aged 1315 years were prioritized in this review because they provide high-quality, nationally representative data within a well-defined regulatory framework, allowing for a clear interpretation of trends in youth tobacco and e-cigarette use ( Multiple factors contribute to the growing popularity of e-cigarettes among youth (Table 1)

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Altered Gut Microbiome & Barrier Function Smoking can also have a negative impact on the microbiome and ultimately leading to impaired tight junctions in the intestinal mucosa, further compromising barrier function and potentially exacerbating UC symptoms