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These changes can cause oxidative modifications to reactive thiols of structurally- or functionally-critical proteins, such as transcription factors 43 , signal transduction molecules 44 or metabolic enzymes 45 , and thereby evoke cellular defense mechanisms against oxidative damage 46

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[DOI] [PubMed] [Google Scholar] [181].Casey PG, Gardiner GE, Casey G, Bradshaw B, Lawlor PG, Lynch PB, et al