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This review discussed the significant effect that E-cig use had on the BC tumor microenvironment, which ultimately led to enhanced tumor malignancy and metastasis, with an emphasis on the extent that E-cig uses had on the crosstalk between cancer and immune cells, as well as the potential underlying mechanisms that drive this aggressive phenotype of BC

E-cigarette aerosol can contain: highly addictive nicotine that can harm brain development ultrafine toxic particles that can interfere with the growth and work of the lungs and increase the risk of heart disease, lung cancer, and asthma attacks harmful heavy metals such as lead, tin, and nickel volatile organic compounds that can cause long-term health effects including cancer

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