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Mood Regulation Nicotines influence on mood is complex, involving multiple neurotransmitter systems that regulate emotional states and stress responses

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In 2024, the WHO reported that the number of tobacco users had fallen from 1.38 billion in 2000 to approximately 1.2 billion

A GWAS of the addiction factor identified 19 significant SNPs, the most significant of which was near DRD2 , and functional enrichment analyses implicated pathways related to neural cells and immune cell processes

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CSE exposure also enriched pro-inflammatory oral genera such as Streptococcus and Aggregatibacter