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HA integrity has also been shown to critically modulate TGF--driven fibroblast differentiation, as enzymatic fragmentation suppresses -smooth muscle actin (-SMA) and collagen type I expression, emphasizing the importance of balanced HA turnover for proper ECM remodeling and scar resolution [9]

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Pathway analysis and tissue expression To identify enriched biological pathways associated with altered tear fluid proteins in amyloid PET-positive and negative participants, we conducted Gene Set Enrichment Analysis (GSEA) in R

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Arch Toxicol 72, 38794

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