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Contraindications: Hypersensitivity Side Effects: CNS Depression (Sedation) & Bradycardia : The most common adverse effects of clonidine are sedation, dry mouth (xerostomia) , fatigue , bradycardia , dizziness, and constipation (Patel and Saadabadi, 2025

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But a new clinical trial concludes they would be better off picking a day to stop and quitting cold

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