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Research on cotinine levels shows pipe smokers absorb substantial nicotine through oral tissues even without inhaling

They would notice a tax increase real quick, Hester said

The psychological and social aspects of smoking, coupled with potential withdrawal symptoms, can make quitting extremely difficult without adequate support

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The discontinuation was driven by (Bergam, 2025) (Figure 2): the availability of newer, safer & more accurate alternative testing for MG including electrophysiological & antibody tests, as well as safety concerns (bradycardia & respiratory complications) limited diagnostic reliability (with both false-positive and false-negative results) The decision to remove edrophonium as an available (alternative) diagnostic test has been challenged (Keritam et al, 2026)

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