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Political lobbying, tobacco advertisements, and industrial innovation are arguably the tobacco companies most essential ingredients for success

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This showed that sensitization of the brain and direct drug activation of the brains dopamine reward-craving system amplified equally the ability of reward cues to trigger excessive wanting. Much more remains to be done before we understand how this process works in humans, with drug rewards such as cocaine and heroin, and to a lesser extent, alcohol or nicotine, says Berridge