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While rates of new infection had dropped significantly in the post-penicillin era, cases have steadily increased year-on-year since the onset of the twenty-first century

According to the 2018 NASEM report, there is substantial evidence that e-cigarette aerosols can induce acute endothelial cell dysfunction a condition that typically causes chest pain

Jawad M, Darzi A, Lotfi T, Nakkash R, Hawkins B, Akl EA (2017) Waterpipe product packaging and labelling at the 3rd international Hookah Fair

And efforts by the FDA to rule on vaping products and their claims were repeatedly slowed by industry lobbying and competing political interests

Retrieved May 3, 2025

These were elaborated in further questionnaires in 1957, 1966, 1971, 1978, and 1991, to which the response rates (after reminders) varied between 98% initially and 94% finally