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Reference Evins, Cather, Culhane, Birnbaum, Horowitz and Hsieh22 There was no evidence of a difference for bupropion compared with control in positive symptoms (standardised mean difference 0.24, 95% CI 0.66 to 0.19), negative symptoms (standardised mean difference 0.12, 95% CI 0.46 to 0.22) or depressive symptoms (standardised mean difference 0.16, 95% CI 0.50 to 0.18)

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Both actions can cause damage to blood vessels

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