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Discussion Fixed doses of NRT can be ineffective for many patients as the given dose can exceed some individuals level of tolerance to nicotine while for others it may be an inadequate dose that fails to sufficiently quell withdrawal and cravings [23]
Method accuracy was previously evaluated by recovery studies in water samples contaminated with cigarette butt leachates, obtaining recoveries between 97 and 104%, demonstrating adequate applicability for nicotine determination in this type of matrix [14]
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