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The combined impact of these aging effects can be significant, leading to a prematurely aged appearance in smokers, often making them appear older than their actual age

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[25] The album's lead-off single, "Somebody Like You", was released in July 2002 and spent six weeks at number one

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Catecholamines and free fatty acids for example, have been reported to also stimulate the synthesis of fibrinogen 22,28 and are elevated after smoking