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It is primarily used orally by placing it into the mouth and chewing
For example, acrolein produces reactive oxygen species leading to endothelial cell dysfunction at exceptionally low concentrations (Yoshida et al., 2009a) and elevates interleukin 6 and C-reactive protein production in clinical populations and experimental models (Saiki et al., 2013
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From a commercial perspective, adult smokers in these regions increasingly exhibit greater brand awareness and willingness to pay for differentiated attributes such as quality of tobacco, flavor profiles, and packaging
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