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(2014) The Health Consequences of Smoking50 Years of Progress: A Report of the Surgeon General, Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, Atlanta

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Additionally, findings from the co-cultured primary gingival epithelial cells and fibroblasts also found increased MMP-1, MMP-2, MMP-3, MMP-9, and disrupted tissue architecture suggestive of epithelial remodeling as well (90)