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Yes, vaping on empty stomach can cause: nausea and dizziness from nicotine absorption without food buffer, increased acid production causing stomach discomfort, dehydration exacerbated by fasting, headaches from nicotine on empty stomach, and potential hypoglycemia symptoms (low blood sugar)

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29 Jan 2009 (doi: 10.1164/rccm.200808-1306OC)