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Furthermore, smoking augments nasal responses to allergen in atopic subjects and increases IgE, immunoglobulin G4 (IgG4), and postallergen histamine levels in nasal lavage fluid [15],[16]

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Sphingosine 1-phosphate induces chemotaxis of immature and modulates cytokine-release in mature human dendritic cells for emergence of Th2 immune responses

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