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Nicotine binds directly to nicotinic acetylcholine receptors in your prefrontal cortex, causing dopamine neurons in your ventral tegmental area to increase their firing rates

Bibcode:2012PLoSO...743838F

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The difference in quit rates between men and women has also narrowed over time, particularly since the mid-1990s, and the rates are converging (Giovino 2004)

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