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The present study complies with the PRISMA guidelines 190 (Supplementary Tables 9 and 10 and Supplementary Information 1.5) and Guidelines for Accurate and Transparent Health Estimates Reporting (GATHER) recommendations 191 (Supplementary Table 11)

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Finally, only 8.9% of these adolescents increased their tobacco use after initiating vaping (n=99), suggesting that vaping had a negative effect on their smoking behavior

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