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One study from the 1990s showed that approximately 50 percent of patients who were followed after inpatient substance abuse treatment died of tobacco-related causes a rate that exceeded deaths from alcohol-related causes (34 percent). Other studies indicate that people with substance use disorders tend to start smoking at a younger age, are more dependent on nicotine, and have a greater risk for some alcohol and smoke-related cancers

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It is worth noting that they found the reduction in pregnancy rate after the assisted reproduction cycles was relevant to current smokers, but not past smokers