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It seems that in 1968, Hendrix started placing cigarettes between the strings and the headstock while playing

Generally the stats in this paper are very poor

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But a growing body of research has exposed a plethora of contaminants and health consequences from cooking with gas

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(15) Other theories for biological mechanism linking smoking to TED have also been proposed: smoking may have a direct irritant action on the eye, causing inflammatory changes, smoking may be a cause of stimulation of the autoimmune process in smokers and smoking may be influence the secretion of cytokine in the eye