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Cigarette smoke affects digestion through multiple mechanisms: Nicotine stimulates the parasympathetic nervous system Inhaled chemicals create an inflammatory response in the gut Carbon monoxide alters blood flow to digestive organs Smoke exposure changes gut microbiome composition Research shows smoking encourages development of certain bowel diseases while potentially deterring others

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See Table 2 and Supplementary Information 4.3 for results for the additional health outcomes with an association with smoking rated as 3 stars

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