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Mucus hypersecretion is a critical histological marker in COPD models (31)

The aim of our study was to determine the impact of tobacco and cannabis on sperm quality, sperm DNA integrity tested by Chromomycin A3 (CMA3) and acridine orange (AO) and their association to genetic variants in the Cytochrome C Oxidase 1, 2 and 3 genes ( MT-CO1 , MT-CO2 , and MT-CO3 )

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The exposure of pulmonary fibroblasts to CSE led to damaged mitophagy, an increase in cell senescence, mtDNA damage, decreased mitochondrial membrane potential, and ATP levels, later restored by a specific mitochondrial antioxidant ( In addition, TGF- can also lead to mitophagy, stabilizing the mitophagy initiating protein PINK1 and inducing mtROS (78, 105)

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