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Key exclusion criteria included the presence of any clinically significant uncontrolled disease, including diabetes, HIV, hepatitis B or C, or other medical condition that, in the opinion of the Principal Investigator, made the individual unsuitable to participate in the study

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A 2019 World Bank study suggests that illicit tobacco trade constitutes only 1.8 % of total tobacco trade in Bangladesh

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Several studies reported that the induction of CYP1A2 determined by smoking cigarette can result in a reduction of plasma levels of drugs that are mainly metabolized by this isoenzyme, with a decrease in therapeutic response [24,25,26,27]