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People generally know that smoking is harmful, but they tend to underestimate how much

it also has phosphatase activity that suppresses signal transduction such as that by JAK and LCK 42,43

As bedaquiline mainly undergoes phase one reactions catalysed by CYP3A4, its exposure may be either reduced or increased during co-administration with inducers or inhibitors of CYP3A4 respectively (Sirturo, 2012)

This increase is similar to the one that occurred in March 2024, when the government raised the purchase tax on cigarettes, e-cigarettes, and roll-your-own tobacco

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