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The pulmonary parenchyma histoarchitecture analysis showed an increase in the volume density of alveolar spaces and a reduction in the volume density of the alveolar septa in animals exposed to regular cigarette smoke compared to control animals, suggesting lung parenchyma damage

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Conclusion So there we have it

For in vivo experiments, both male and female mice were exposed to one puff of nicotine or cannabidiol aerosols for five days a week