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Cunningham said

Smoking upregulates alpha4beta2* nicotinic acetylcholine receptors in the human brain

State Nicotine products, including, but not limited to tobacco products (cigarettes, cigars, e-cigarettes, vaping products, pipe tobacco, snuff, chewing tobacco, dipping tobacco) and vapor material (liquid or other solutions or material containing nicotine or synthetic nicotine that is depleted as an electronic cigarette or any product made or derived from tobacco that contains nicotine

JAMA 311:1356 [DOI] [PubMed] [Google Scholar] 3.Adriaens K, Van Gucht D, Declerck P, Baeyens F

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Its use for smoking and perfuming homes has been mentioned already