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Indeed, albeit e-cigarettes are claimed as safer than traditional smoking, their aerosol contain metals, toxic and carcinogenic molecules and a growing body of evidence in man has been showing how their use negatively impact both cardiovascular and respiratory systems, causing elevated blood pressure, arterial stiffness, vascular endothelial dysfunction, enhanced angiogenesis, cardiorenal fibrosis, accelerated atherosclerotic plaque development, elevate levels of type 2 inflammatory cytokines such as IL-4, IL-5, and IL-13, increased cellular oxidative stress, increased airway reactivity, airflow obstruction, airway inflammation, and emphysema

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On the other hand we did find that those with COPD had significantly increased granulocytes and, in response to HIV-1 stimulation, significantly lower levels of IL-1

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Such an approach entails soft-touch law enforcement combined with a vigorous public health agenda

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