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Ferroptosis is induced by disruption of glutathione synthesis or inhibition of glutathione peroxidase 4, exacerbated by iron, and prevented by radical scavengers such as ferrostatin-1, liproxstatin-1, and endogenous vitamin E

GHK-Cu also modulates gene expression through mechanisms that remain incompletely characterized but involve broad transcriptomic changes affecting over 4,000 human genes as identified through Connectivity Map (CMAP) analysis

PubMed Aminian, A., Zajichek, A., Arterburn, D.E., Wolski, K.E., Brethauer, S.A., Schauer, P.R., et al

2023;11:e003197