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8.1.3 Metformin and other metabolic modulators Metformin, primarily known as an anti-diabetic medication, has been found to inhibit mitochondrial ATP and DNA synthesis, which can abrogate NLRP3 inflammasome activation and reduce pulmonary inflammation
Its anti-inflammatory and antipruritic effects were significantly diminished in MRGPRX2-overexpressing mice, indicating that its primary mechanism involves modulation of the MRGPRX2/ORAI1/ORAI2 axis (177)
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3 The practice entered western pharmacopoeia in 1802 after a Scottish doctor visiting India reported that smoking traditional stramonium cigarettes had relieved his asthma
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