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Therefore, keep your dog away from ashtrays or products containing nicotine (cigarettes, cigarette butts, patches, or nicotine gum)

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Nicotine, cotinine and 3-hydroxy-cotinine (OH-cotinine) were measured in PBS using a quantitative liquid chromatography coupled to tandem mass spectrometry (LCMS/MS) method, based on a previously validated method for saliva (as established in 39 )

Decreased blood circulation Tobacco smoke contains chemicals that damage the small blood vessels in the body and decrease blood flow, including to the small blood vessels that supply the scalp with oxygen and nutrients (known as microcirculation) (Leone, 2013)

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