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The low heterogeneity observed in studies on current users (I 2 = 0%) suggests consistent results, while the moderate heterogeneity for former and ever users emphasizes the need for further research to explore the complexities of e-cigarette exposure and its role in COPD development

In January 2010, the FDA lost a lawsuit from manufacturers opposed to its plan to regulate e-cigarettes as drug-delivery devices, but it has yet to complete the rulemaking process that would extend its oversight of ordinary tobacco products to cigars and e-cigarettes, which are increasingly popular among teenagers

This pattern can persist for years

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This shift intensified during the 1960s counterculture movement, when rolling paper companies recognized cannabis users as a distinct market segment requiring specialized products

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