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This data highlights varying trends in smoking prevalence across different regions, with most areas seeing a decline in smokers, except for the African and Eastern Mediterranean regions, where the numbers are rising

On average, smokers die more than 10 years earlier than nonsmokers

Finally, future efforts should also focus on (emerging) trends such as cannabis smoking and e-cigarette use in the light of ED and CVD risk

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Social acceptance and regulations differ across regions, with heated tobacco often viewed more favorably and vaping facing stricter restrictions in some areas

Our prior work identified body mass index (BMI) as a genetically correlated trait to SmkInit that mediated effects of SmkInit on type 2 diabetes (T2D) risk [25]