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At the methodological level, all selected studies were of good methodological quality, although the quality of evidence according to GRADE is low or very low in most cases

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Safety and Side Effects of Cannabidiol, a Cannabis Sativa Constituent

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Additionally, findings from the co-cultured primary gingival epithelial cells and fibroblasts also found increased MMP-1, MMP-2, MMP-3, MMP-9, and disrupted tissue architecture suggestive of epithelial remodeling as well (90)