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When autophagy is dysregulated by factors such as smoking, environmental insults and aging, it can lead to enhanced formation of aggressors and production of reactive oxygen species (ROS), resulting in oxidative stress and oxidative damage to cells

[accessed 22 Jan 2011];Tobacco Plain Packaging Act

This was previously an uncommon disease

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The initiative provides assistance for creating global public health policy, encourages mobilization between societies, and supports the World Health Organization Framework Convention on Tobacco Control (FCTC)