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As well as heavy metals like nickel, tin and lead

and Industry Transformation

Nicotine is also thought to contribute to the hardening of your blood vessels and the development of blood clots, both of which can lead to a higher risk of heart attack or stroke

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For examples and a current list of jurisdictions with flavored tobacco sales restrictions or ban in place see: States & Localities That Have Restricted the Sale of Flavored Tobacco Products, Campaign for Tobacco Free Kids Local restrictions on flavored tobacco and e-cigarette products, Truth Initiative US Sales Restrictions on Flavored Tobacco Products, Public Health Law Center Some jurisdictions have also passed policies that indirectly reduce the availability of flavored tobacco products

As a general rule, 1000 puffs is often considered equivalent to about 5 packs of cigarettes