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Animals exposed to e-cigarettes had a particularly high level of cytokines interleukin 1 beta (IL-1) and tumor necrosis factor alpha (TNF-), compounds that may damage the delicate barrier that regulates the transport of nutrients between the eye and the bloodstream, the study authors wrote

In vitro nicotine exposure has been shown to activate leucocytes and promote release of myeloperoxidase acutely, and this impaired Ach mediated vasodilation 42 , as we also observed