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Nicotine patches are generally considered halal if used for medical purposes like quitting smoking

Oral leukoplakia also arises in non-smokers and non-alcohol drinkers, suggesting a potential genetic predisposition

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For Study 2, data from a prior study was used as an estimate to obtain 30 subjects as the minimum number of subjects needed to have at least 80% chance of obtaining 95% confidence interval with half width up to 20% of the means for the primary endpoints 46